Adalimumab-linked reversible lentiginosis

The heart in lentiginosis.

Lentiginosis or hyperactivity of the melanocytes in skin presents in children as multiple small pigmented spots and thus may be erroneously diagnosed as von Recklinghausen's disease (Moynahan, i962), but there are no neurofibromata and there may be other associated systemic disturbances such as somatic infantilism, short stature, and cardiac abnormalities. Walther, Polansky, and Grots (I966) de...

Lentiginosis and left atrial myxoma.

Reversible proteinuria after adalimumab discontinuation in a patient with Crohn's disease

fluorodeoxyglucose activity in the thicken wall of AAA (Figure 1B). A renal biopsy specimen showed interstitial nephritis with patchy pattern infiltration of plasma cells (Figure 1C). Immunostaining of anti-IgG4 antibodies detected that a lot of IgG4-positive plasma cells infiltrated into the interstitium, compatible with IgG4-positive multiorgan lymphoproliferative syndrome (IgG4+MOLPS) (Figur...

Reversible Corpus Callosal Lesions Associated with the Use of Adalimumab for Ulcerative Colitis

Dear Editor, A reversible corpus callosum lesion is a unique phenomenon with an unclear pathophysiology. Various etiologies may underlie the lesion, including toxins, encephalitis, influenza A, metabolic disorders such as hypernatremia, hypoglycemia, and vitamin deficiency disorders.1 In rare cases the lesion is caused by immunomodulating therapies.2 We report a patient with a reversible corpus...

The reversible phase transition of DNA-linked colloidal gold assemblies

We present direct evidence for a reversible phase transition of DNA-linked colloidal gold assemblies. Transmission electron microscopy and optical absorption spectroscopy are used to monitor the colloidal gold phase transition, whose behavior is dominated by DNA interactions. We use single-stranded DNA-capped colloidal gold that is linked by complementary linker DNA to form the assemblies. We f...